الفهرس 
AscitesOnly 14 pages are availabe for public view
 |  | from | 131 |  |  |
| | | from | 131 | | |
Abstract
Background: Spontaneous bacterial peritonitis (SBP) is a potentially fatal condition, characterized by infection of ascitic fluid in absence of any intra-abdominal surgically treatable source of infection.Diagnosis of SBP is based on a differential ascites leucocytic count. Aim of the Work: to assess the role of ascitic fluid calprotectin in diagnosis of SBP. Patients and Methods: A cross sectional study was conducted on 60 patients with decompensated liver disease were selected. They were divided into: 1) Non SBP Group: included 30 patients with cirrhotic ascites without clinical or laboratory evidence of spontaneous bacterial peritonitis. 2) SBP Group: included 30 patients with cirrhotic ascites and spontaneous bacterial peritonitis. Results:. Ascitic fluid calprotectin level and the ratio of calprotectin to total protein was statistically significant higher in SBP group than non SBP group. There was a significant decrease in total protein and albumin in ascitic fluid in SBP group compared to non SBP group .A significant positive correlation was detected between ascitic fluid calprotectin and ascitic fluid TLC and PNLs among SBP group, A significant positive correlation between the ratio of calprotectin to total protein and ascitic fluid TLC and PNLs among SBP group. Asitic fluid calprotectin at cut-off value 96 ng/ml, had a sensitivity 86.67 % and a specificity 76.67 % in diagnosis of SBP with positive predictive value 85.2 % and negative predictive value 78.8%. - The ratio of calprotectin to total protein at cut-off value 9.6, had a sensitivity 96.67 % and a specificity 90 % in diagnosis of SBP with positive predictive value 96.4 % and negative predictive value 90.6%. Conclusion: The ratio of calprotectin to total protein had high sensitivity and specificity in diagnosis of SBP and better than calprotectin alone. The ratio of calprotectin to total protein could be a useful diagnostic test for SBP.