الفهرس 
Acknowledgements
Analgesic effect of xylazine HClOnly 14 pages are availabe for public view
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Abstract
The present study aimed to evaluate xylazineHCl as an anesthetic for laparo-gastrotomy operation in dogs at different doses with special regard to its anaesthetic indices, effect on physiological parameters, blood gases, and biochemical parameters. It was conducted on 27 clinically healthy, adult dogs. The dogs were divided randomly and equally into three groups based on the dose of the drug used, group (A, 4 mg/kg), (B, 8 mg/kg), and (C, 14 mg/kg). Onset on anesthesia was 4, 3.5+ 0.33, 5 + 0.33 min, and the duration was 18 + 2.5, 21+ 7.2, and 28 + 4.3 min in the groups A, B, and C, respectively. The rectal temperature exhibited non-significant decrease. Dogs in three groups of anesthesia recorded a non-significant decrease in the respiratory rate. There was a non-significant decrease in the heart rate. During the anesthetic period, dogs in all groups showed non-significant changes regarding the PH level. There was significant increase in all groups in the PCO2 level. The dogs in groups B and C exhibited significant decrease in SO2. Significant hyperglycemia was manifested in the groups A, B, and C. Serum cortisol level decreased in the groups (B) and (C), where the decrease was significant in the group (B). The group (A) recorded a non-significant increase. Dogs in the group (A) recorded a significant increase in the NO level, while there was a non-significant change in the group (B) and (C). There was significant increase in MDA levels in the dogs of the group (B), while there was non-significant decrease in the groups (A) and (C). Creatinine level recorded non-significant decrease in the group (A), while there was a non-significant increase in the group (B). There was non-significant decrease in GGT levels in the groups A and C.
The present study explored that xylazine at doses of 14 mg/kg giving a satisfactory stable anesthesia of duration time (28± 4.3min) that was enough to conduct laparogastrotomy operation in dog with minimal changes in physiological, biochemical, and blood gases indices.