الفهرس 
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Abstract
Diabetes mellitus (DM) is a group of metabolic disorders categorized by a
chronic hyperglycemic condition resulting from defects in insulin secretion, insulin
action or both, There are two types of diabetes type 1 and type 2 (insulin-dependent
diabetes and non-insulin-dependent diabetes ) , Diabetes can lead to complications
in the long and short term that affect many parts of the body including the brain,
eyes, heart, kidneys and nerves.
Glimepride is an antidiabetic oral hypoglycemic drug from second generation
sulfonylurea. Glimepride stimulates insulin secretion by binding to a high-affinity
subunit of the beta-cell - ATP- sensitive potassium channel (KATP channel). Binding
results in blocking of K+ efflux through the KIR6.2 channel, depolarization of the
beta cell, opening of voltage-sensitive Ca++ channels, influx of Ca++.
The aim of this study was conducted for evaluating the antidiabetic effect of
Moringa Oleifera on diabetic rats compared with glimepride .
Experimental protocol :
In this study, fifty adult male albino rats were classified into five equal groups
(each of ten):
• group 1: Normal nondiabetic rats.
• group 2: Diabetic nontreated rats .
• group 3: Diabetic rats orally administered glimepride (0.3mg/kgb.wt) for 45
successive days.
• group 4: Diabetic rats, orally administered Moringa oliefera (250mg/kgb.wt)
for 45 successive days.
• group 5: Diabetic rats orally administered glimepride (0.3mg/kgb.wt) and
moringa (250mg/kgb.wt) for 45 successive days.
The diabetes was induced in rats by administration of nicotinamide at a dose
of 210 mg/kg b.wt. followed by 55 mg/kg b.wt of freshly prepared STZ
intraperitoneally, Samples were taken at the end of experimental period.