الفهرس | Only 14 pages are availabe for public view |
Abstract Diabetes mellitus (DM) is a group of metabolic disorders categorized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both, There are two types of diabetes type 1 and type 2 (insulin-dependent diabetes and non-insulin-dependent diabetes ) , Diabetes can lead to complications in the long and short term that affect many parts of the body including the brain, eyes, heart, kidneys and nerves. Glimepride is an antidiabetic oral hypoglycemic drug from second generation sulfonylurea. Glimepride stimulates insulin secretion by binding to a high-affinity subunit of the beta-cell - ATP- sensitive potassium channel (KATP channel). Binding results in blocking of K+ efflux through the KIR6.2 channel, depolarization of the beta cell, opening of voltage-sensitive Ca++ channels, influx of Ca++. The aim of this study was conducted for evaluating the antidiabetic effect of Moringa Oleifera on diabetic rats compared with glimepride . Experimental protocol : In this study, fifty adult male albino rats were classified into five equal groups (each of ten): • group 1: Normal nondiabetic rats. • group 2: Diabetic nontreated rats . • group 3: Diabetic rats orally administered glimepride (0.3mg/kgb.wt) for 45 successive days. • group 4: Diabetic rats, orally administered Moringa oliefera (250mg/kgb.wt) for 45 successive days. • group 5: Diabetic rats orally administered glimepride (0.3mg/kgb.wt) and moringa (250mg/kgb.wt) for 45 successive days. The diabetes was induced in rats by administration of nicotinamide at a dose of 210 mg/kg b.wt. followed by 55 mg/kg b.wt of freshly prepared STZ intraperitoneally, Samples were taken at the end of experimental period. |