الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 124 |  |  |
| | | from | 124 | | |
Abstract
Transient tachypnea of the newborn (TTN) is a self-limited disease commonly seen in neonates throughout the world. Infants with TTN present within the first few hours of life with tachypnea and other signs of respiratory distress, increased oxygen requirement, and ABGs that do not necessarily reflect carbon dioxide retention. The TTN has been reported to occur more frequently in preterm birth, cesarean delivery, maternal sedation, perinatal asphyxia, maternal asthma and birth of male infant.
Enzyme leakage as a result of hypoxia-ischemia-induced cell damage in affected organs is well known. Lactate dehydrogenase (LDH), lactate, aspartate aminotransferase (AST) and elevated normoblast counts are good predictors of perinatal asphyxia. The substantial rise in LDH and AST after organ damage and asphyxia directly after birth (cord blood), resulting from organ damage following asphyxia and their different rates of disappearance from plasma (5–36 h), make these enzymes potential predictors of the severity of the hypoxic-ischemic insult in the perinatal period.
This study aimed to assess the predictive values of lactate and LDH as hypoxia determinants in predicting the risk for prolonged oxygen requirement and respiratory support requirement in the TTN patients.
This study is a prospective cross-sectional study that was conducted on 80 full-term neonates born ± 37 weeks of gestational age who were admitted immediately or shortly after birth in the neonatal intensive care unit (NICU) Benha University Hospital and Benha Insurance Hospital between the dates of first of May 2018 to October 2018.
Newborns were divided into two groups: Control group: included 30 neonates, 20 males and 10 females, with mean of gestational age 38.20±1.29 weeks, and cases group (TTN): included 50 neonates, 23males and 27 females with mean of age 37.83±1.19 weeks.
Control group (III): included 30 neonates, 20 males and 10 females, with mean of gestational age 38.20±1.29 weeks, and cases group (TTN): included 50 neonates, 23 males and 27 females with mean of age 37.83±1.19 weeks.
Cases is divided into subgroups according to the severity of the disease:
1. Supplemental oxygen group (I) :with O2 supplementation through incubator o2 or nasal prong.
2. Respiratory support group(II):with respiratory support through nasal CPAP or mechanical ventilation.
All neonates were subjected to careful history taking including, thorough examination, and full panel of investigations: CBC, CRP, ABG, and Plain chest X-ray. Assessment of AST, LDH and serum lactate.
Results of the current study show statistically significant higher Serum Lactate, LDH and AST in group II compared to group (I) and group (III) (p <0.001, 0.001 & 0.001 respectively).
In conclusion, we suggested that LDH might be useful for clinicians at first level hospitals for decision making to refer the TTN patient to the secondary or tertiary level NICU before the clinical situation is worsened.