الفهرس 
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Abstract
Hepatitis C is an infectious disease caused by the hepatic C virus (HCV) that primarily affects the liver. Hepatocellular carcinoma (HCC) represents the main complication of cirrhosis that are induced by chronic HCV. Therefore, searching for natural compounds against HCV infection, since the latter is tremendous importance, the major high risk populations of HCC.The aim of this work is to study the effect of the combination of magic fruit and honey bee on patients with chronic HCV infection. The patients were given 4 gm from Magic fruit (Ziziphus jujube) and 1 gm from Honey bee 3 times daily for three months.Patients and methods: The study was conducted on a total of 50 patients with chronic hepatitis C (35 males and 15 females with median age 45 years). These patients were taken from the outpatient clinics of National Cancer Institute- Cairo University, Egypt.Results: The mean values of virus C level by PCR analysis showed highly significant decrease after treatment with the combination of the magic fruit and honey bee. In addition the results have shown improvements in liver function, kidney function, and CBC tests in HCV patients post-treatment. Moreover the results revealed also that, highly significant decreased of CD4 + CD25 expression by flow cytometric analysis was observed in the mononuclear leukocytes isolated from the patients after treatment. Conclusion: A combination of magic fruit and honey bee could be useful protective natural agents against human hepatocarcinogenesis induced by HCV infection.