الفهرس 
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Abstract
Background: Cerebral arteriovenous malformations are the most common type of cerebrovascular malformationArteriovenous malformations (AVM) of the brain are complex tangles of abnormal vessels that result in the direct arteriovenous shunting of blood. Understanding the exact molecular mechanisms of AVM formation and progression is critical for developing novel therapies such as the vascular targeting therapy and the gene therapy Previous studies have demonstrated that brain AVMs are associated with cerebral hemodynamic changes as well as molecular mechanisms involved in abnormal angiogenesis and local inflammatory responsesMoreover, some cytokines, such as vascular endothelial growth factor (VEGF), interleukin 6 (IL-6), myeloperoxidase (MPO), participate in theses molecular mechanismsIn particular, vascular endothelial growth factor (VEGF), a potent endothelial cell mitogen, is thought to play a key role. Increased VEGF expression has been demonstrated in the endothelium, sub-endothelium, and adventitia of resected AVM specimens. More recently, one study reported significantly elevated circulating VEGF levels in AVM patients compared to healthy controlsVascular endothelial growth factor (VEGF) is a vascular growth factor, which induces angiogenesis (the development of new blood vessels), vascular permeability, and inflammation. In brain, receptors for VEGF have been localized to vascular endothelium, neurons, and glia Patients and Methods:A case-control study conducted on 54 subjects, subdivided into 3 groups.The patients subdivided into three groups: 10 patients: AVM with seizures. 16 patients: AVM without seizures. 28 subjects (control) The sample of this study consists of 26 patients with AVM admitted to Neurology and neurosurgery departments, Mansoura University Hospital for investigation or treatment Aim of the work:This study is designed to evaluate the role of vascular endothelial growth factor in arterio-venous malformation associated seizures Results: We measured the serum level of VEGF in all the 54 subjects. The study showed a statistically significant higher mean of VEGF among AVM cases in comparison to control group.Conclusion: Our research confirmed the Role of vascular endothelial growth factor in epilepsy and AVM.