الفهرس 
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Abstract
Hemophilia is one of the most frequent inherted bleeding disorders nowadays. Hemophilia has an incidence of 1 in 5000 (Hemophilia A) and in 25000 (Hemophilia B) males, respectively. No ethnic or geographic predisposition has been noted.
There are continuous progress and researches to improve the treatment of hemophilia from the past till now to diminish any complications of hemophilia itself or its treatment.
Hemophilia as a chronic disease has psychological effect over the children who are often deprived of regular life activities because of the fear of recurring episodes of bleeding. Their families also have feelings of anger, and guilt toward their children. As result,their siblings may assume extra care-giving tasks for their overburdened parent, leading to poorer quality of life.
Anxiety disorders constitute a category of mental disorders characterized by feelings of fear. Fear manifests as a reaction to current events, while anxiety is worry concentrated on future events. Depressed mood can be a feature of major depressive disorder. Individuals with clinical depression can experience feelings of sadness, fatigue, guilt, worthlessness, lack of concentration, irritability, suicidality and changes in sleep, appetite and /or activity.
The aim of the current study was; to detect the prevalence of anxiety and depression among haemophilic children and their sibling as control group and to study some of the possible risk factors, which may affect the rate of incidence of anxiety and depression among the hemophilic children.
This study was adopted on 93 hemophilic and 103 control children. All children were aged (6-18) years and had no other chronic medical or surgical conditions; to preclude the effect of other illness.
For the evaluation of anxiety and depression symptoms among the studied children, self-reporting scales were used including; children depression inventory scale (CDI) and children manifest anxiety scale (CMAS).
In this study it was found that among hemophilic patients;26.9% had mild depression, 54.8% had moderate depression and 18.3% had severe depression, while among their sibling it was 67% with low score for depression, 32% had moderate score for depression and only 1% had high score for depression. It was statistically significant difference between cases and control regarding depression.
Regarding to Anxiety it was found in the current study that hemophilic children had variant degrees of anxiety as follows; 4.3% with mild anxiety, 55.9% with moderate anxiety and 39.8% with severe anxiety. In the opposite side among control group; 64% had mild anxiety, 29.1% had moderate anxiety and 6.8% had severe anxiety. It was statistically significant difference between cases and control regarding anxiety.
In the current study there was statistical significance between depression and some risk factors as; consanguinity, socioeconomic status, frequency of plasma/cryo transfusion and some points of joint arthropathy scale like flexion contracture, muscle atrophy and joint axial deformity. However, the study did not find statistically significant relationship between depression and frequency of hospital admission, chronic joint pain, affection of joint range of motion, joint swelling nor crepitation during motion.
As regard anxiety, the current study found that there is statistically significant relationship between anxiety and some risk factors as; consanguinity, socioeconomic status, and affection of joint range of motion,but didn’t find statistically significant relationship between anxiety and other risk factors as; frequency of plasma/cryo transfusion, frequency of hospital admission nor any of the other points of joint arthropathy.