الفهرس 
Metal Complexes of 2-Hydrazinopyridine Thiosemicarbazide DerivativesOnly 14 pages are availabe for public view
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Abstract
Thiosemicarbazides and their transition metal complexes had been known since 1895. Their derivatives have raised considerable interest in biology due to their pharmacological properties and in chemistry due to the formation of highly stable and intensely colored complexes with wide variety of stereochemistries which are used for spectrophotometric determination of metal ions in different media. They exist as thione-thiol tautomers and can bind to the metal ion in neutral or anionic forms. In both tautomeric forms, the binding to metal ion occurs via S or S and N. The work in this thesis aims firstly to the synthesis of new thiosemicarbazide ligand, 4- chloro -1- (pyridin-2-yl) thiosemicarbazide and its complexes with Co(II), Ni(II), Cu(II), Zn(II), Ag(I), Pd(II) and Pt(II). The complexes were characterized by elemental, spectral (IR, UV-Vis and NMR) and thermal analyses. Moreover, the antibacterial and cytotoxic activities of the ligand and its metal complexes were examined. Secondly, it aims to use of 4- chloro -1- (pyridin-2-yl) thiosemicarbazide and 4-(p-tolyl)-1-(pyridin-2-yl)thiosemicarbazides as chelating agents for the separation and preconcentration of Cu (II), Ni (II), Zn (II), Cd (II), Co (II), Pb (II), Fe (II), Hg (II), Pt(II), Pd(II), Au(III) and Ag(I) from aqueous medium by cloud point technique, prior to determination by GFAAS (Hg was determined by HGAAS). The thesis comprises of two main chapters. The first chapter, Metal Complexes of 2-Hydrazinopyridine Thiosemicarbazide Derivatives, consists of three sections: The first section, Introduction, includes a literature survey on 2-hydrazinopyridine complexes. It was indicated that 2-hydrazinopyridine plays an important role in the synthesis of complexes used in the cytotoxin delivery for therapy and synthesis of diagnostic radiopharmaceuticals used in majority of the diagnostic scans. The complexes derived from 2-hydrazinopyridine with a wide variety of aldehydes and ketones had a considerable interest. Moreover, rhenium complexes of 4-t-butyl and 4-phenyl-1-(pyridin-2-yl) thiosemicarbazides were used for radiopharmaceutical application. The second section, Experimental, includes a list of reagents, stock solutions along with the analyses, physical measurements and instrumentation (IR, UV-Vis., 1H-NMR, MS, magnetic and thermal) as well as a description for the preparation of the ligand and its metal complexes.