الفهرس 
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Abstract
This study aimed to investigate of the clinicobiochemical findings associated with experimentally induced hypomagnesemia in Ossimi rams. Also, evaluate of the impact of using L-Carnitine therapy in treatment of experimentally induced hypomagnesemia in Ossimi rams.Hypomagnesemia was induced in ossimi rams by administration of potassium chloride (1.39) gm/kg b.wt and citric acid (1.19)gm/kg b.wt daily,orally by stomach tube till appearance of the characteristic symptoms of hypomagnesemia . All animals were used as experimental animals for induction of hypomagnesemia until the clinical signs of hypomagnesemia were appeared then the animals were classified into (2) groups according to trials of treatment group 1 (T1): 5 animals treated with the traditional treatment of hypomagnesemia as the following: First dose: -Magnesium sulfate 20% 50 ml i.v - Magnesium sulfate 20% 50ml s.c -Magnesium chloride 25 gm orally single dose-Calcium gluconate (calcionate ampoule ) slow i.v-Dextrose 5% i.v-Vitamin AD3E +B.Complex i.m Second dose :(After 12 h) : Magnesium sulfate 20% 50 ml s/c group 2 (T2) : 5 animals treated with the previos treatment in addition to injection of L-Carnitine with a dose (20) mg/kg b.w I.V The symptoms of hypomagnesemia appeared gradually until complete appearance of symptoms at day 28 post induction. Asignificant (p< 0.05) decrease in Mg level was observed at the day 14,21 and 28..while the Ca level began to be decreased when the Mg level falls below (1.48±0.08)mg/dl then at the day 28,there was significant(p< 0.05) decrease in Ca level. Potasium level was significantly (p< 0.05) increased at the day 14,21 and 28. While there was significat(p< 0.05) increase in chloride level at the day 21 and 28. Also, there was significant (p< 0.05) increase in Na level at the day 21 and 28. Urea and Creatinine levels were significantly (p< 0.05) increased at the day 14,21 and 28. Glucose level was significally (p< 0.05) decreased at the day 21 and 28.while there was significant (p< 0.05) increase in AST level at the day 21 and 28.on the other hand there was no significant change in the level of Total protiens. Cortisol level was significally (p< 0.05) increased at the day 28.while the level of PTH was significally (p< 0.05) decrease at the day 28 . CK was significally (p< 0.05) increased at the day 14,21 and 28. While there were significant (p< 0.05) increase in the levels of LDH and ALP at the day 21 and 28 . CTnI was significally (p< 0.05) increased at the day 14,21 and 28.By comparing the two lines of treatment, the clinical findings of hypomagnesemia disappear in case of traditional treatment with L-Carnitine earlier and more rapid than traditional treatment only. The animals resume their appetite and general condition. rectal temperature, ruminal movement ,pulse and respiration rates returned to normal levels more pronounced with L-Carnitine therapy.The treatment of hypomagnesemic rams with traditional treatment in addition to L-Carnitine resulted in significant(p< 0.05) elevation of serum Mg and Ca levels with significant(p< 0.05) decrease in serum K, Na and CL levels than traditional treatment only. Also there was significant(p< 0.05) decrease in serum urea and creatinine levels in traditional treatment with L-Carnitine than traditional treatment only.On the other hand there was significant (p< 0.05) elevation in serum glucose levels with significant(p< 0.05) decrease in AST levels in case of traditional treatment with L-Carnitine than traditional treatment only. Also the results revealed significant (p< 0.05) decrease in serum Cortisol level with significant(p< 0.05) increase in serum PTH levels in case of traditional treatment with L-Carnitine than in case of traditional treatment only. Additionally,there was significant (p< 0.05) decrease in serum CK, LDH and ALP levels in case of traditional treatment with L-Carnitine than in case of traditional treatment only. Also ,cTnI levels were significally increased after 24 hour from treatment with traditional treatment with L-Carnitine than with traditional treatment only.