الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
HCC is one of the most dangerous malignant tumors and is the most common cause of cancer related death worldwide. Egypt has a high prevalence of hepatocellular carcinoma (HCC). This high prevalence in Egypt is related to the high rate of viral hepatitis C and B and environmental risks. A large portion of HCC patients are diagnosed in advanced stage making the medical intervention difficult or impossible and this makes the prognosis worse. Early diagnosis of HCC is very important to increase the chance of effective treatment and reduce the HCC related mortality. Abdominal ultrasound and checking of serum alpha-fetoprotein (AFP) level are recommended for patients with chronic liver diseases. However the accuracy of ultrasound depends greatly on the operator skill and can’t differentiate between malignant and nonmalignant focal lesions similarly, AFP has a limited sensitivity. Normal AFP values were reported in many HCC patients while AFP may be elevated in some benign hepatic focal lesions as well as non-hepatic malignancies.Many authors tried to evaluate the value of different biomarkers in HCC diagnosis aiming to improve the diagnostic accuracy as well as the prognosis. Glypican-3 (GLP-3) is one of these promising biomarkers.GLP-3 is an oncofetal protein, GLP-3 is expressed abundantly in the fetal liver, minimally expressed in the normal adult liver.