الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Scarring is a distressing outcome of acne, as it causes cosmetic and psychological problems to the patients. Unfortunately no single treatment is satisfactory, instead employing multiple modalities may have better outcome.
Autologous Adipose tissue-derived adult stem cells (AT-ASCs) and their secretory factors can stimulate collagen synthesis, angiogenesis and migration of fibroblasts thus regenerate damaged tissues. Also conventional treatments for acne scarring, such as lasers and topical regimens, induce new collagen synthesis via activation of dermal fibroblasts or growth factors.
The aim of this work was to evaluate the efficacy and safety of Autologous Adipose derived Stem cells in treatment of post acne scars in comparison to fractional CO2 laser resurfacing.
This study was carried out on twenty five patients complaining of post acne scars. Twenty patients completed the study, the other five paients discontinued the treatment plan. All the patients were recruited from the Department of Dermatology and Venereology Outpatient Clinic, Faculty of Medicine, Alexandria University.
Each patient received two treatment modalities .The right side treated with single session of intradermal AT-SCS injection and the left side received three sessions of FXRC.
Assessment was done by photography using the global scoring system Goodmans and Barons, scar area percent using NIH ImageJ software and functional assessment by measuring the trans-epidermal water loss (TEWL), skin hydration and skin homogeneity and texture. In addition, patients satisfaction questionnaire and assessment of side effects were carried out.
According to Goodmans and Barons qualitative grading score there was no significant difference between both treated sides before treatment denoting acne scar severity grade at baseline.
The degree of scar severity after treatment on both sides, comparing the same side before and after treatment, a significant decrease in the scores at the right side , where the grades declined to grade II and III (18 and 2 cases respectively). Similarly, on the left side 12 cases were assessed as grade II and 8 cases as grade III, showing a significant improvement of the scoring grade compared to that before treatment.
After treatment both sides showed significant difference for both treatment modalities when compared to pre-treatment. However no significance difference was noted between both sides of the face after treatment had been accomplished.
The present study could show the efficacy of a single AT-ASCs injection versus three sessions of FXRC in the treatment of atrophic post acne scars and thus avoiding the later side effects and the needed compliance of the patient to pay, at least, three visits across the three month treatment duration to achieve the same satisfying results.
Further studies done on larger population groups may define precisely the role played by various cells in dermatological conditions, thereby enabling formulation of newer cell based therapies.