الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The present thesis is devoted for developing new methods for the analysis of certain drugs used for treatment of cardiovascular diseases, namely: hydrochlorothiazide (HCZ), telmisartan (TEL), sotalol hydrochloride (SOT), Valsartan (VAL), amlodipine besylate (AML), aspirin (ASP), atorvastatin (ATR) and ramipril (RAM) either in pure form, in pharmaceutical preparations and/or biological fluids and in content uniformity testing. The principles of the proposed procedures as well as the experimental parameters and proposal schemes of the reactions were studied, discussed and explained. Furthermore, the data given were statistically analyzed and compared with those obtained by the comparison methods. Different analytical techniques were applied for determination of the studied compounds. Two analytical methods including Q-absorbance spectrophotometry and micellar liquid chromatography with UV detection were developed for the simultaneous determination of HCZ and TEL in tablets. Analytical eco-scale was done for assessment of the two methods. A stability‐indicating spectrofluorimetric method for the determination of SOT in tablets and human plasma was developed. Another sensitive micellar reversed- phase liquid chromatographic method with UV detection was developed for determination of VAL and AML in their co-formulated dosage forms. The method was further applied to content uniformity testing and the determination of AML in spiked human plasma. Spectrophotometric methods for the determination of ASP, ATR and RAM in their ternary mixture and prepared tablets were developed. The four methods included Derivative spectrophotometry (DSZ), Ratio derivative spectrophotometry (DRSZ), double divisor-ratio spectra derivative DDRD and hybrid double divisor ratio spectra method (HDDR), and a micellar reversed phase liquid chromatographic method with UV detection and application of that method to content uniformity testing of ramipril.The validation criteria of the developed methods were intensively studied. All the results were statistically analyzed and compared with those given by official or comparison methods.