الفهرس 
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Abstract
Background: Oral mucositis induced by Cetuximab drug is associated with remarkable morbidity or permanent treatment discontinuation and therefore the use of ginger would be beneficial in treatment of mucositis. In this study we aimed to evaluate the effect of Ginger on the inflammatory reaction induced by Cetuximab drug through COX-2 immunoexpression in tongue mucosa of experimental rats.
Material and Methods: 8 rats and 16 archival blocks were used, divided into 3 groups: a control group (8 archival blocks), Cetuximab group (8 archival blocks), group III (8 rats received Ginger by oral gavage in parallel with Cetuximab). Tongue dissection was performed at euthanization date. Area percent of the immunohistochemical expression of COX-2 was measured by software Leica Qwin 500.
Results: COX-2 was expressed in epithelium of Cetuximab group and loss of this expression was found in normal tongue mucosa and Cetuximab + Ginger group. A statistically significant difference in COX-2 expression was present between Cetuximab group and Cetuximab + Ginger group.
Conclusion: Ginger administration can reduce inflammation caused by Cetuximab drug in tongue mucosa of rats.