الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The present study included (68) selected HCV positive patients classified into patients with hepatic fibrosis(20) , patients with Child-turcotte-Pugh (CTP) A cirrhosis(14), patients with CTP B cirrhosis(15), and patients with CTP C cirrhosis (19). In addition to healthy control subjects (20) with matched age and sex . In this study, the mean age of all groups is between 48.4 10.4 and 50.5 5.9 . All the patients in all groups were subjected to complete history taking, complete physical examination, complete laboratory investigations including serum iron parameters(serum iron , s.ferritin, s.TIBC and TS) , pelvi-abdominal ultrasound and the severity of the liver disease was determined using Child Classification.This study was conducted to describe the effect of chronic liver disease on serum iron tests and its relation to presence or absence of anemia. In the current study we have been evaluated iron parameters in each studied group. Our study shows that serum iron parameters especially serum ferritin and TS significantly increased with increase severity of liver disease. In contrast to serum TIBC which showed significant decrease with increase severity of liver disease. Unlike serum iron, there was no significant difference between all study liver disease groups as regard Iron levels. Iron deficiency anemia is a frequent complication of advanced liver disease. The etiology is multifactorial, mostly due to chronic hemorrhage into the gastrointestinal tract. The diagnosis of iron deficiency anemia is very challenging, as simple laboratory methods, including serum iron, ferritin, transferrin saturation (Tsat), and mean corpuscular volume are affected by the liver disease itself or the cause of the disease, resulting in difficulty in the interpretation of the results. Once iron deficiency anemia is diagnosed, it should be treated with oral or parenteral iron as well as portal pressure reducing drugs. Blood transfusion is reserved for symptomatic anemia despite iron supplementation.