الفهرس 
VitiligoOnly 14 pages are availabe for public view
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Abstract
Summary
Vitiligo is an acquired pigmentary disorder of the skin and
mucous membranes which manifests as white macules and patches due
to selective loss of melanocytes. Etiological hypotheses of vitiligo
include genetic, immunological, neural, cytotoxic, biochemical,
oxidative stress and newer theories of melanocytorrhagy. There are
several types of vitiligo which are usually diagnosed clinically and by
using a Wood’s lamp.
Several treatment options are available for treatment of vitiligo
that aims to stop disease progression and/or to attain repigmentation or
even depigmentation, but traditional treatments seems to be inadequate.
Phototherapy has been the cornerstone for treatment of vitiligo
for years. The combination of topical prostaglandin F2α with
phototherapy and laser has been tried with promising results.
Prostaglandin F2α acts through direct effects of on melanocyte
tyrosinase activity and dendricity, and indirectly through FP receptor
(prostaglandin F receptor) regulation.
The aim of this work was to evaluate the safety & efficacy of
intralesional injection of prostaglandin F2α on the outcome of narrow
band U.V.B in treatment of resistant cases vitiligo.
In this study, 27 vitiligo patients were treated with intralesional
injection of prostaglandin F2α in combination with narrow band UVB
on one patch and narrow band UVB alone in another patch.