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العنوان
Uses of chalcone in synthesis of some interesting
heterocyclic compounds containing mixed and nonmixed
systems /
المؤلف
Saad,Marwa Hosny Ahmed.
هيئة الاعداد
باحث / Marwa Hosny Ahmed Saad
مشرف / Maher Abed El-Azize El-Hashash
مشرف / Magda Ismail Marzouk
مشرف / Abeer Mohamed El-Sayed El-Naggar
تاريخ النشر
2019
عدد الصفحات
245p.:
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الكيمياء
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

from 245

from 245

Abstract

New pyrazole, oxazole and pyridine derivatives bearing
naphthalene, furan and dimethylaminophenyl moieties have
been prepared by condensing 3-(furan-2-yl)-1-(naphthalen-2-
yl)prop-2-en-1-one 1 and /or and 3-(3-(dimethyl amino)
phenyl)-1-(naphthalen-2-yl) prop-2-en-1-one 2 with different
nitrogen and carbon nucleophiles such as hydrazine,
hydroxylamine, cyclohexanone, cyclopentanone, ethyl
cyanoacetate and malononitrile, respectively. Elemental and
spectroscopic evidences characterized all the newly
synthesized compounds. All of the newly synthesized
compounds were tested in vitro for their anti-proliferative
activities against HePG-2 and MCF-7 cell lines.
Keywords: chalcone, pyrimidine, cytotoxic activity.