الفهرس 
VitiligoVitiligo Vitiligo VitiligoVitiligoOnly 14 pages are availabe for public view
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Abstract
Vitiligo is an acquired idiopathic and progressive skin disease characterized by loss of functioning epidermal melanocytes. The prevalence of vitiligo is approximately 0.5-1% worldwide. Although the exact cause of vitiligo is unknown, vitiligo is thought to result from complex pathogenetic mechanisms involving a combination of environmental and genetic risk factors. Oxidative stress is considered to be the initial pathogenic event in the melanocyte destruction.Nuclear factor erythroid 2 - related factor 2 (Nrf2), is a transcription factor essential for protecting cells and tissues from oxidative stress-induced injury. Nrf2 regulates the basal and inducible expression of detoxifying and antioxidant genes. Nrf2 dysfunction might be involved in the pathogenesis of human diseases.The aim of this study is to investigate the association of the single nucleotide polymorphisms (SNPs) in Nrf2 promoter region with the susceptibility to vitiligo and assessment of its clinical significance among a sample of Egyptian vitiligo patients.This study included 100 patients suffering from vitiligo. In addition, 50 apparently healthy individuals of matched age, sex and body mass index (BMI) will be included as a control group. All patients were selected from the outpatient clinic of Dermatology, Andrology and Venereology Department of Banha University Hospitals. A written informed consent was obtained from all participants. The study was approved by the local ethics committee on research involving human subjects of Banha Faculty of Medicine. Disease activity was assessed by vitiligo area severity index (VASI).