الفهرس 
AORTIC VALVE CALCI-SCLEROSISOnly 14 pages are availabe for public view
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Abstract
SUMMARYCalcific aortic valve disease is a slowly progressive disorder with a disease continuum that ranges from mild valve thickening without obstruction of blood flow, termed aortic sclerosis, to severe calcification with impaired leaflet motion or aortic stenosis. In the past, this process was thought to be “degenerative” because of time-dependent wear-and-tear of the leaflets with passive calcium deposition. Now, there is compelling histopathologic and clinical data suggesting that calcific valve disease is an active process (Rosario et al., 2005). The overlap in the clinical factors associated with calcific valve disease and atherosclerosis and the correlation between the severity of peripheral arterial diseases and aortic valve calcification provide further support for a shared disease process (Otto, 2005).
Because PAD has a high prevalence of cardiovascular comorbidity, Acurate assessment of PAD could be useful in preventing further atherosclerotic morbidity and mortality by providing an early indication of the need for intervention.
Many studies on the prognostic value of AVS & PAD have been done & proved that both are associated with high cardiovascular morbidity and mortality (Losi, et al., 2010).The present study was conducted on 100 patients with sclerocalcific aortic valve disease diagnosed by routine transthoracic echocardiography, presented to Ain Shams university hospital and Misr international hospital. We studied the prevalence of PAD in patients with AVS. Most of patients share nearly the same traditional risk factors of atherosclerosis, and we excluded all patients with history of chronic renal insufficiency (i.e., creatinine >1.5 mg/dl), prosthetic aortic valve, rheumatic valvular heart diseases, Poorly echogenic aortic valve. All patients were subjected to ABI assessment and peripheral arterial disease was diagnosed by an ABI <0.95.
All selected patients were subjected to full history taking, routine laboratory investigations: Fasting Blood Sugar, Kidney function tests (serum Creatinine), lipid profile (serum cholesterol, LDL). Echocardiography (2D, M mode & Doppler) for all patients. Then all patients were subjected to ABI assessment.
In the current study PAD was found in 31% of patients with aortic sclerocalcific changes.
Our study proved that age, smoking, HTN, DM and dyslipidemia are strong risk factors in patients with AVS for developing PAD. Also the higher the mean systolic PG across the AV and the presence of MV calcification in echocardiography in patients with AVS mean that the patient is at a higher risk for developing PAD.This study directs our attention to wide field of research involving the difference between the various bad prognostic indicators of the atherosclerotic process. So we suggest to study the difference between AVS & PAD as regard to cardiovascular morbidity & mortality and we suggest also to study the time range between AVS patients who will develop PAD & PAD patients who will develop AVS and correlating that with the different risk factors of atherosclerosis & making that work on a larger population.