الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Jaundice is the most common condition that requires medical attention in newborns, serum bilirubin levels may raise excessively, which is neurotoxic and can cause death in newborns and lifelong neurologic squeal. Although phototherapy is the standard treatment for neonatal hyperbilirubinemia, it may lead to potential side effects as increased apoptosis. P53 is a tumor suppressor protein described as “the guardian of the genome” because of its role in conserving stability by preventing genome mutation. One of the most dramatic responses to P53 activation is the induction of apoptosis. The present study was conducted on 22 patients with neonatal hyperbilirubinemia necessitating phototherapy (12 males and 9 females), and 11 patients with neonatal hyperbilirubinemia not necessitating phototherapy serving as control group one (7 males and 4 females), and 11 apparently healthy subjects without neonatal hyperbilirubinemia serving as control group two (6 males and 5 females). All patients and controls were subjected to full history taking and clinical examination. In addition to laboratory investigations including: bilirubin mg/dl, Hb g/dl, Reticulocytes count %, Coomb’s test, Blood and Rh grouping, P53 U/L.