الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Necrotic primary molars are one of dental caries sequelea. Necrotic pulp may result in other sequelea including abscess formation, sinus, bone or root resorption and finally loss of teeth.
Challenges in management of necrotic primary molars is related to complexity of root canal anatomy and complexity of root canal bacteria. Regarding complex anatomy, primary root canal contains multiple accessory canals, lateral branches, apical deltas or ramifications. Beside this there is complexity of biofilm of necrotic pulp.
So the aim of the current study was to compare a newly introduced material which is a combination of triple mix antibiotics paste and anti-hyperlipidemia drug simvastatin, the new material is named 3MIX-TATIN & was compared to calcium hydroxide iodoform paste for management of necrotic primary molars by using Lesion Sterilization and Tissue Repair LSTR technique.
In this study, subjects were selected from the outpatient clinic of Pediatric Dentistry Department, Faculty of Dentistry Cairo University. This aided to standardize the socioeconomic and educational status, most of subjects families there were regular attendee so it made the follow up sessions more accessible to them.
In this study one hundred non-vital primary molars were included and randomly allocated into two groups. Both groups were treated by Lesion Sterilization and Tissue Repair Technique. In group (A) calcium hydroxide iodoform paste was used as a medicament, on the other hand in group (B) 3mixtatin which is a mixture of three antibiotics and simvastatin was used.
Clinical evaluation of primary outcome (postoperative pain) recorded at 9th month follow up was 0.0% for group A with no cases reported with pain, and 9.5% for group B with 4 cases reported with pain. Clinical failure accompanied by radiographic failure was considered when treatment was stopped and shifted to either extraction or pulpectomy. Regarding clinical failure at 9th month follow up 8(17.3%) subjects from group (A) were reported with clinical failures, compared to 10(20%) subjects from group (B).
Regarding radiographic failure was considered when there was increased furcation radiolucency, increased external/ internal root resorption or periapical radiolucency. Radiographic evaluation at 9th month follow up showed furcation radiolucency in 42.9% of subjects in group (A) compared to 33.3% in group (B). Internal or external root resorption was reported in 42.9% in group (A) compared to 19.3% in group (B). In spite of clinical success number of cases showed radiographic failure in group (A) 10(21%) subjects showed criteria of radiographic failure, whereas in group (B) 2(4%) subjects. Bone regeneration was found in both groups but there was a significant increase in group (B) with much less cases presented with unfavorable radiographic outcomes.