الفهرس 
Chapter 1: IntroductionOnly 14 pages are availabe for public view
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Abstract
Series of Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II),
Pb(II), and Sr(II), complexes of new dehydroacetic acid hydrazone have been
prepared and characterized using elemental analyses, IR, UV-Vis, 1H- and 13CNMR,
Mass spectra, Magnetism, Conductance, Thermal analyses (DTA and
TGA) and ESR measurements. Elemental and spectral analyses indicate, the
complexes are distorted octahedral structure. The conductance show non-ionic
character. The Cu(II) complexes show anisotropic character (dx2-y2) with
considerable covalent bond character, however, Co(II) and Mn(II) complexes
show isotropic type confirming octahedral structure. Interface between
structural biology and chemistry may provide the most productive means for
discovering and improving upon novel anticancer agents. Invitro cytotoxic
evolution of the ligand and some of its metal complexes against HepG-2 cell
line have been carried out. The obtained results show enhanced activity of the
complexes in comparison to the parent ligand or a standard drug (Doxorubicin)
especially Sr(II), Cd(II), Cu(II) and mixed Cu(II) / Zn(II) complexes relative to
IC50.