الفهرس 
Coronary Artery DiseaseOnly 14 pages are availabe for public view
 |  | from | 163 |  |  |
| | | from | 163 | | |
Abstract
C
oronary artery disease has become the leading contributor to the burden of disease worldwide, as assessed on the basis of disability-adjusted life-years. In Egypt, it is responsible for 21% of deaths and reported a prevalence of 8.3%. It is a complex, multifactorial, silent progressive disease, caused by multiple genetic variants in combination with various environmental and lifestyle factors. CAD is characterized by long-term atheromatous plaque formation which culminates into athero-thrombotic obstructive lesions leading to tissue damage.
Cyclophilin A is a protein secreted from various types of cells, including endothelial cells, monocytes, vascular smooth muscle cells (VSMCs), and platelets in response to inflammatory stimuli, such as hypoxia, infection, and oxidative stress. The secretion of CyPA is regulated by activation of Rho-kinase and oxidative stress specifically in VSMC, which plays a crucial role for inflammation, vascular contraction, and the development of atherosclerosis.
The present study assessed serum levels of CyPA in patients with CAD, to investigate the association between CyPA levels and CAD severity.
For this purpose, samples were collected from sixty-eight (68) patients undergoing clinically indicated coronary angiography at the Cardiology Department of Ain Shams Hospitals. In addition to, twenty-one (21) sex -and age- matched subjects served as the control group, referred due to chest distress but angiography findings showed free coronaries. According to the results of the coronary angiography, patients were further classified according to the number of diseased vessels into 4 subgroups; 12 patients had 0 vessel disease, 21 patients showed 1 vessel disease, 21 patients had 2 vessel disease and 14 patients had 3 vessel disease. Patients with histories of previous catheterization, recent myocardial infarction, major trauma or surgery, and valvular or congenital heart disease were excluded.
The study revealed that levels of CypA were significantly higher among studied atherosclerotic CAD patients when compared to the control group (p<0.01). Also, patients with zero vessel disease showed significantly higher CyPA levels than control group (p<0.05); suggesting the role of this marker in early detection of the atherosclerotic process. Moreover, zero vessel disease patients significantly differed in their CyPA levels compared to 1, 2, and 3 vessel disease patients; (p<0.05).
On the other hand, the differentiation between more advanced conditions of the CAD, wasn’t revealed in our study. There was no significant difference in the CyPA levels among the patients’ groups starting from 1 vessel disease till the 3 vessel disease.