الفهرس 
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Abstract
Amoebiasis is a severe infection caused by Entamoeba histolytica, and it is considered an important cause of morbidity and mortality in the world. Metronidazole is the major drug of choice and other nitroimidazole derived compounds like tinidazole, secnidazole and ornidazole are equally effective.
Nigella sativa (N. sativa) is emerging as a miracle herb with a rich historical and religious background since many researches revealed its wide spectrum of pharmacological potential. N. sativa is commonly known as black seed.
The current study was conducted as a double blinded randomized clinical trial to compare effectiveness of N. Sativa and metronidazole as an oral therapy for E. histolytica infection.
The patients recruited in the study were the children and adolescents aged (6-18) years with E. histolytica infection attending El-Mahsama Family Practice Center which serves the rural community of El-Mahsama village in Egypt.
The study procedures consisted of 2 phases; in the first phase the eligible patients with positive stool analysis for E. histolytica (using wet mount stool analysis technique), who attended El Mahsama Family practice center were randomly sampled.
In phase 2, the diagnosed patients with positive stool analysis for E. histolytica who were willing to participate in the study were simply randomized into two equally matched groups; 33 patients in intervention and 34 patients in control.