الفهرس 
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Abstract
Hepcidin and Erythroferrone are very important mediators on iron metabolism in the body. Hepcidin acts by binding to ferroportin; known as cellular iron exporter and the erythroid regulator erythroferrone (ERFE) mediates hepcidin suppression during increased erythropoietic activity.
The aim of this study is to assess the level of Erythroferrone (ERFE) gene (FAM123B) protein, hepcidine level in the serum of patients with beta thalassemia major also to study the relation between Erythroferrone, hepcidin and ferritin and their value as a diagnostic marker in iron overload in patients with beta thalassemia major. To achieve this, a total number of 40 adult cases of beta thalassemia major have been recruited from the Clinical Hematology Division, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Hepcidin and Erythroferrone have been measured in the blood of the cases by using ELISA technique.
The majority of study group showed highly significant relation between hepcidin and erythroferrone in their blood samples. The P-value was <0.001 between them in the studied group.
This was not associated with correlation between both groups-the cases of beta thalassemia major and controls- in
Summary
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terms of demographic data as age, weight and BMI and clinical data as HCV infection and lab data as TLC and Hb F with p value 0.674, 0.139, 0.202, 0.048, 0.015 and 0.818 respectively