الفهرس 
VITAMIN DOnly 14 pages are availabe for public view
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Abstract
Background: Vitamin D (Vit D) deficiency (<20ng/ml) or insufficiency (20-30 ng/ml) are common in pediatric patients with severe hemophilia A and patients with type 1 diabetes mellitus (T1DM). It affects bone mineral density (BMD) which is assessed by Dual Energy X-ray Absorptiometry (DEXA) scan (osteoporosis ≤-2.5 z-score and osteopenia -1≥ z-score > -2.5).
The aim of this study was to measure 25-hydroxyvitamin D level in patients with severe hemophilia A and those with T1DM and correlate it to their DEXA scan score, glycemic control and the presence of microvascular complications in T1DM and annual bleeding rate in severe hemophilia A.
Methods: This 1-year cross-sectional study was conducted on 50 patients with T1DM and 50 patients with severe hemophilia A who were compared to 50, age and sex matched, healthy controls. They were recruited from Pediatric diabetes clinic and hematology clinic, Ain Shams University. All participants were subjected to full history, examination, laboratory investigations included hemogram, serum 25(OH)Vit D, calcium, phosphorus, alkaline phosphatase, glycosylated hemoglobin (HbA1c), lipid profile, ALT, urea, creatinine; urine analysis for microalbuminuria and DEXA scan.
Results: The mean patients’ age was 13.56 years (9 – 16). Vit D deficiency and insufficiency were demonstrated in 56% and 22% respectively in T1DM, and 97% deficiency on severe hemophilia A. Mean Vit D in our diabetics and hemophilics was correlated with their DEXA scan score. An inverse correlation was found between mean Vit D and HbA1C, diabetes duration, and presence of microvascular complications in patients with T1DM and joint score in patients with severe hemophilia.
Conclusion: Vit D deficiency (<30 ng/ml) was related to longer diabetes duration, elevated HbA1C and presence of microvascular complications in patients with T1DM and annual bleeding rate and joint score in patients with severe hemophilia A. Hence, Vit D supplementation might help in control of diabetes and possible delay or prevention of its microvascular complications in diabetics and improve mobilization and quality of life in hemophilics.