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العنوان
Effect of Dexamethasone on the Duration of Induction of Labor at Term :
المؤلف
Mahmoud, Safaa Elhussieny.
هيئة الاعداد
باحث / صفاء الحسينى محمود
مشرف / حازم فاضل الشهاوى
مشرف / محمد سعيد الدين الصفتى
مشرف / رشا محمود مدحت عبد الهادى
تاريخ النشر
2019.
عدد الصفحات
156 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية الطب - أمراض النساء و التوليد
الفهرس
Only 14 pages are availabe for public view

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from 156

Abstract

Normal labor is essential gate has been known throughout life of humanity of having cohorts of humanity. Timing is a major determinant of its success. Scientists throughout centuries have been studying how to shorten its duration to decrease the complication, how to have easy normal gate.
Different techniques tools and methods are being in test and advance. Science is a hungry boy does stop over a limit in our research we tried to test the effect of intramuscular dexamethasone on the delivering normal parturants who will apply to induction, does it open a gate to decrease time, does it decrease phases? So we randomly choose 140 pregnant females who fulfill the normal type parturant criteria and randomly divided them into 2 equal groups “A” group is a symbol of once who took our drug under study, and “B” group is for once who did not and took a placebo blindly we followed each group analyzed data and saw what happened.
Method of administration
It includes 140 women candidate for induction of labor distributed into two groups.
group A (Dexamethasone group) n=70
Eight mg (2ml) of the product dexamethasone sodium phosphate was administrated intramuscularly 6 hours before initiation of labor induction; and labor induction was performed by standard protocol, i.e, starts by 5 drops /minute of 500 cc saline + 5 units of oxytocin with the dose increases by 5-10 drops / minute every 30 minute till optimal contractions are reached (3uterine contractions in 10 minutes and lasting for 40-50 seconds each).
group B (Control group) n=70:
Two ml of distilled water was administrated intramuscularly 6 hours before initiation of labor induction; and labor induction was performed by the same protocol as above. The interval between initiation of induction and beginning of the active phase of labor (cervical dilatation of 3–4 cm plus 3 forceful contractions over a 10-minute span),the duration of active phase and the duration of 2nd and 3rd stages of labor was compared between the two groups.
Inclusion criteria:
1. Primipara.
2. Age (20-30)
3. Gestational age (38-41) weeks according to a reliable date for the last menstrual period and a first-trimester ultrasound evaluation.
4. Vertex presentation.
5. Single fetus.
6. Not in labor.
7. No contraindication for vaginal delivery.
8. Good bishop score (>7)
Exclusion criteria:
1. Indication for cesarean section e.g. CPD, Placenta previa, IUGR, Non vertex presentation and previous cesarean section.
2. Maternal medical disorders as diabetes mellitus and sever pre-eclampsia.
3. Active phase of labor (cervical dilatation of 3-4 cm plus 3 forceful contractions over a 10minute span).
4. Preterm labor and premature rupture of membranes.
5. Multiparous women.
6. Significant vaginal bleeding. Placenta previa, probable placental abruption.
7. Fetal macrosomia > 4 kg (estimated by u/s).
8. Cervix with a poor bishop score (4-7)
9. Multiple pregnancy
10. Non-cephalic presentation
What is pleasant is that it is yes shorten duration of labor and its phases.
Data analysis gave us not only significant results but highly significant results in shortening time of labor with no significant change of systolic blood pressure nor fetal heart rate which frighten us as complications which may attend with use of such a drug which didn’t happen. Safety is present and this is the goal of our science.
So in brief words, Dexamethasone intramuscularly prior to induction yes significantly shorten duration of normal labor in normal parurants with minimal complications.