الفهرس 
Apolipoprotein E gene polymorphismOnly 14 pages are availabe for public view
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Abstract
SFI are one of the most prevalent skin diseases worldwide. According to clinical reports, dermatophytosis has been the most prevalent form of superficial infections.
ApoE is polymorphic with three common alleles (e2, e3, and e4) coding for 3 isoforms (ε2, ε3, and ε4), which produce 3 homozygous (e2/e2, e3/e3, and e4/e4) and 3 heterozygous (e2/e3, e2/e4 and e3/e4) phenotypes in the human population.
ApoE is a 34.2 kDa protein that is incorporated into serum lipoproteins and directs their catabolism via binding to receptors. ApoE modulates the catabolism of triglyceride-depleted remnants of chylomicrons (CM) and VLDL.
No data are available for the relationship between ApoE polymorphism and serum lipid levels or other SFI risks factors in Egypt. We conducted this prospective case-control study on 50 patients suffering from SFIs and 50 apparently healthy individuals as a control group to evaluate ApoE gene polymorphism (rs 429358) and serum lipids profile in patients with superficial fungal diseases.
Each patient was subjected to full history taking, complete dermatologic examination, laboratory investigations (serum levels of TC, Gs µscopic direct examinations performed with 20% KOH) and determination of ApoE (rs429358) gene polymorphism by polymerase chain reaction
The present study results showed that BMI was significantly higher in patients than control group, and history of animal contact was significantly higher in patients than control group.
Also, the present study results showed that serum levels of TC, TGs and LDL-C were significantly higher in patients when compared to control group.
The current work showed that ApoE (e2e3, e2e2, e2e3+e2e2) isoforms and e2 allele was significantly higher frequency in studied patients when compared to control groups, with higher risk to develop superficial mycosis.
The present study results showed that there was significant difference between ApoE isoforms (e3e3, e2e2) frequency regarding dermatophyte infection.
In current study, patients with candidiasis were older in age when compared to patients with TVC or dermatophytosis. Serum levels of TC and LDL-C were significantly higher in patients with candidiasis and TVC infections.
Also, in the present study ApoE (e2e3, e2e2, e2e3+e2e2) isoforms showed significantly higher frequency in patients with animals contact history. While ApoE (e2e2) isoform showed significantly higher frequency in patients with family history.There was significant difference between ApoE isoforms frequency regarding the disease duration, oncet and course.There was significant difference between ApoE isoforms frequency regarding site of infections (skin, nails and hair).