الفهرس 
Epidemiology, Etiology & Management Principles of Early Invasive Breast Cancer
Approach for patients who underwent mastectomyOnly 14 pages are availabe for public view
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Abstract
Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer deaths in women worldwide, accounting for 23% of total cancer cases and 14% of all cancer related mortalities.
This study investigated the prognostic effect of chemotherapy-induced amenorrhea (CIA) on disease-free survival and overall survival in premenopausal patients with breast cancer following adjuvant chemotherapy.
A retrospective analysis was conducted over 192 female patients diagnosed with invasive non-metastatic breast cancer presented to Clinical oncology department at Ain-Shams University hospitals. All patient’s records in 2014 were reviewed allowing four years overall survival and disease-free survival follow up. All these data were collected through chart analysis. Data concerning patient characteristics, clinical picture, tumor characteristics, surgical details and adjuvant treatments received were thoroughly collected.
In the current study, many of the parameters addressed were almost like worldwide incidences with little variations. Mean age at diagnosis was 40 years. As regards staging of patients, TNM staging system according to the American Joint Cancer Committee (AJCC), (T2) was the most common finding among patients (67.2 %) and (T1) was the least representing only 3.6%.
N0 was the most common presentation among our population representing 35.9% whereas N2 represented 22.9%. N3 was the least, representing 13.5%. IDC was the most common pathological subtype. 66.7 % of the patients were ER-positive and 58.3% were PR-positive. Her2 receptors were overexpressed in only 26.6% of the cases.
152 patients received sequential anthracycline and taxanes (79.2%), 38 patients (19.8%) received anthracyclines only, while those who received CMF regimen were only 2 patients (1%).
Most of the patients underwent modified radical mastectomy (53%) rather than breast conserving surgery. All patients received adjuvant treatment. Most of patients with HR-positive tumors received adjuvant hormonal treatment.
Chemotherapy induced amenorrhea was elicited in 127(66.1%) patients. On analysis of different predictive factors for chemotherapy-induced amenorrhea, age at time of diagnosis and the addition of hormonal treatment were found to influence the occurrence of CIA.
Analyzing the effect of CIA on DFS and OS using survival analysis performed by using Kaplan- Meier method; superior DFS and OS were noticed in patients who experienced CIA where median DFS was found to be 47 months and median OS of 49 months.