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العنوان
Minimal Residual Disease in Acute Myeloid Leukemia patient
الناشر
faculty of medicine
المؤلف
Mahmoud,Ibrahim Jamal
هيئة الاعداد
باحث / إبراهيم جمال محمود
مشرف / الأستاذ الدكتور/ محمد محمود متولي موسى
مشرف / الأستاذ الدكتور/ عماد عبد المحسن عبد الهادي
مشرف / الدكتور/ نور الهدى حسين عبد الله
الموضوع
Acute Myeloid Leukemia
تاريخ النشر
2019
عدد الصفحات
130 P.
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية التمريض - الأمراض الباطنية
الفهرس
Only 14 pages are availabe for public view

from 130

from 130

Abstract

All the patients with low risk are alive, 7 patients of the intermediate risk are alive representing 23% of the total number, while 5 patients of high risk are alive representing 16% of the total number which exhibits statistical significance with P-value 0.032.
Positive MRD is associated with higher mortality rates, exhibiting a statistical significance with P-value of 0.005
This means that there is a positive correlation between the detection of MRD post treatment and the fate of patients with acute myeloid leukemia.
We concluded that assessment of minimal residual disease in AML is of great value in determination of prognosis of the disease and its outcome and it is of great value to determine the levels of minimal residual disease (MRD) during the course of therapy and to stratify patient to identify high risk patient and to plan the therapeutic program accordingly.
In addition we explore that the level of MRD and cytogenetic abnormalities influence the fate of patients after chemotherapy and additional measures may be needed later on to protect patients with myeloid malignancy from relapse.