الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Cancer is the major problem facing the whole world and Egypt in particular. Liver cancer incidence and mortality is increasing in the world and in Egypt. Unfortunately, there is no direct cause, but it is possible to say that there are some causes such as drinking alcohol, cigarette smoking, pollution resulting from the spread of factories and ionizing radiation exposure are implicated in almost cancer types. In addition to these causes, liver cancer for example Hepatocellular carcinoma (HCC) increase also as a result of infection by hepatic viruses such as hepatitis B virus (HBV) and hepatitis C virus (HCV).
This type of cancer is treating by removal of the infected part of the liver or whole and trying to transplant liver. Also, radiotherapy and chemotherapy are used. Radiotherapy and chemotherapy always lead to harmful side effects in all body parts of the patients, so the traditional treatments try to take a chance to treat the tumor with no unfortunate side effects.
Polyphenols is a natural product present in large quantity and low price. Polyphenols such as curcumin, hesperidin and quercetin exhibit its ability to act as anticancer, anti-inflammatory, anti-angiogenesis and antioxidants.
This work concern to study these products and its ability to overcome the tumor and enhance the effect of γ-radiation.
The results illustrated that the polyphenol compounds are all benefit in tumor treatment. Curcumin in high concentration above 10µM lower the number of viable cells and this effect increase by the time also hesperidin and quercetin respectively. And in the same context total antioxidant decreased in curcumin and hesperidin treated groups, but with quercetin total antioxidant increased. The exposure to γ-radiation lowered the cell viability and TAC especially in 5Gy than in 2Gy. When 5Gy combined with the previous compounds the effect of cell death increased and TAC decreased, but in case of quercetin TAC increased. Concerning gene expression, level of p53 increased with all treatments especially with high concentrations, but expression of Her2/neu and MMP9 decreased in all treatments.
Conclusion:
The use of ionizing γ- radiation can stop the propagation of cancer and the use of natural products as polyphenols (curcumin, hesperidin and quercetin) with radiation can improve the effect of γ- radiation to overcome the cancer cells.