الفهرس 
PULMONARY STENOSISOnly 14 pages are availabe for public view
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Abstract
C
ongenital heart malformations are the most frequent of all major birth defects, with an estimated prevalence at birth of approximately 8-10 cases per 1000 births. Amongst congenital heart disease, pulmonary valve stenosis (PS) accounts for 10% of congenital heart diseases and is accompanied in approximately 20% of congenital heart disease cases. The traditional treatment for pulmonary valve stenosis prior was surgical valvotomy. Nowadays balloon pulmonary valvuloplasty has become the treatment of choice for relief of pulmonary valve stenosis.
One of the complications noticed post-BPV is the right ventricular outflow tract (RVOT) obstruction resulting in residual dynamic gradient across the right ventricular infundibulum. Such complication may become quite significant and lead to the so-called “suicide RV”.
Our aim was to assess the role of beta blockers on functional capacity and cardiac hemodynamic following BPV in patients with congenital pulmonary stenosis.
Our study was designed to be a prospective, case controlled trial with two parallel groups that included fifty patients presenting for elective BPV at Cardiology Department at El-Demderdash hospital, Ain Shams University, Cairo, Egypt in the time interval between January 2018 and August 2018. The 50 patients were equally distributed into 2 arms; BB arm and placebo arm. The BB arm received 2 mg/kg of propranolol daily into two divided doses for 1 month while the placebo arm received age appropriate vitamin supplements for one month as a placebo.
Our results found no significant difference detected between the two arms regarding functional capacity and RV echocardiographic parameters at 24 hours and at 1-month post-BPV. For both the placebo and the BB arms, a significant improvement in functional capacity and some RV echocardiographic was noticed in the duration from 24 hours to 1 month reflecting the excellent follow up course for BPV. Regarding percent change from data collected at 24 hours and data collected at 1 month post-BPV, no significant changes were found between the placebo arm and the BB arm.
In conclusion, the routine use of beta blocker for patients without infundibular spasm post BPV does not provide any additional benefit within the immediate and short term follow up periods.