الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 95 |  |  |
| | | from | 95 | | |
Abstract
Non-steroidal anti-inFlammatory drugs (NSAIDs) are effective analgesic and anti-inFlammatory drugs that form the main pharmacological approach to treat various forms of pain, and particularly chronic musculoskeletal pain, but have a number of known adverse erects. NSAIDs are associated with upper and lower gastrointestinal harm, acute renal failure, and congestive heart failure.
Although the adverse effects of acute and long-term use of many NSAIDs were extensively reported, their potential contribution in erectile dysfunction in experimental animals has not been investigated despite the important role played by prostaglandins in the control of erection peripherally, taking into consideration also the close association between cardiovascular and erectile functions. To our knowledge, only one clinical study reported that the use of NSAIDs increases the risk of erectile dysfunction.
Prostanoids may be involved in contraction of erectile tissues via PGF2 and thromboxane A2, stimulating thromboxane and FP receptors and initiating phosphoinositide turnover, as well as in relaxation via PGE1 and PGE2, stimulating EP receptors (EP2/EP4).
PGE1-induced relaxation of human corporal smooth muscle was also suggested to be related to activation of KCa channels, resulting in hyperpolarization. Escrig et al. found that repeated PGE1 treatment enhances erectile responses to nerve stimulation in the rat penis by up-regulating constitutive NOS isoforms. Prostanoids may also be involved in inhibition of platelet aggregation and white cell adhesion, and some data suggest that prostanoids and transforming growth factor-1 may have a role in modulation of collagen synthesis and in the regulation of Wbrosis of the corpus cavernosum.
PGE1, injected intracavernously or administered intraurethrally, is currently one of the most widely non-orally used drugs for treatment of erectile dysfunction.
The aim of the work to study the effect of ibuprofen on erectile process in rates. The current study may provide preliminary information about the relative side effect of NSAIDs and may highlight one of the aspects of druginduced erectile dysfunction.
This study was carried out on 40 adult male Wistar albino rats. The rats were divided randomly into one control and three groups of ibuprofen treated rats.
Measuring level of prostaglandin E1 and prostaglandin F2 α in cavernous tissue after homogenization by ELISA. Histopathological examination of the cavernosal tissue by H &E.
The results of this study show that PGF2α and PGE1were lower in cases in comparison with control group. Area of collagen around the cavernous tissue was higher in treated group more than control group.