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العنوان
Impact of Residual Kidney Function on Mineral Bone Disorders in Hemodialysis Patients /
المؤلف
Mohamed, Ahmed Ra’fat Yousif.
هيئة الاعداد
باحث / Ahmed Ra’fat Yousif Mohamed
مشرف / Osama Mahmoud Kamal
مشرف / Haitham Ezzat Abdelaziz
مناقش / Mostafa Abd El-Nassier Abd El-Gwad
تاريخ النشر
2018.
عدد الصفحات
154 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2018
مكان الإجازة
جامعة عين شمس - كلية الطب - قسم الباطنة العامة
الفهرس
Only 14 pages are availabe for public view

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from 154

Abstract

Mineral and bone disorders, characterized by abnormal serum concentrations of calcium, phosphorus, intact parathyroid hormone, and alkaline phosphatase, are common complications in patients with CKD, especially in those with ESRD [(KDIGO. 2009)]. However, those abnormalities may be attenuated in patients on hemodialysis with substantial residual kidney function who maintain greater solute clearance (Mathew AT, et al. 2016).
Preserved RKF also offers other clinical benefits, including lower ultrafiltration volume, less intradialytic hypotension, and lower prevalence of anemia as well as decreased progression rate of malnutrition, inflammation, erythropoietin resistance, and ventricular hypertrophy (Mathew AT, et al. 2016). Indeed, several studies have suggested that frequent hemodialysis is beneficial to those with little or no RKF but may be detrimental to those with substantial RKF (Chertow GM, et al. 2016).
The study was done on 100 patients on regular hemodialysis, three sessions per week, in dialysis unit of Shebin ElKom Teaching Hospital. Patients were divided into three groups according to urine output (UOP) in 24 hours :
• group 1 (UOP > 50 ml \ 24h),
• group 2 (0 < UOP < 50 ml\ 24h),
• group 3 (no UOP)
we measured corrected calcium, phosphorus, iPTH, hemoglobin level and calculated KT\V per session then compared these parameters with residual kidney function (RKF) which was calculated by Daugirdas method.
Residual kidney function (Kru ) =
( UUN ÷ SUN ) × urine flow rate (ml\min)
( Handbook of Dialysis, 5th edition,2015 )
All three groups were compared regarding corrected Ca, phosphorus, iPTH , hemoglobin level, Kt\v and residual kidney function .
There was a significant difference between three groups regarding hemoglobin level, kt\v, corrected Ca, iPTH and residual kidney function with P value (0.006), (0.001), (0.001), (0.032) and (0.001) respectively. On the other hand, there was no significant difference between three groups regarding phosphorus with P value (0.838)
Residual kidney function is an important tool to assess remaining of kidney function and may improve bone mineral disorders if it is preserved, but still the phosphorus out of its control and may be affected by other factors need to be more studied.