الفهرس 
WartsOnly 14 pages are availabe for public view
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Abstract
Warts are caused by Human Papilloma Virus (HPV), a double-stranded DNA virus. Warts have a variety of clinical manifestations depending on the viral type and site and are usually treated by a wide variety of methods including cryotherapy, surgical excision, podophyllin, bleomycin and various lasers. Each mode of therapy has its own complications and failure rates.
The treatment of patients with multiple, recalcitrant or recurrent verrucae continues to be a challenging task for both primary care physicians and dermatologists. Previously mentioned methods are not always successful and may be associated with severe adverse events. Even when existing warts are successfully eradicated, patients may develop new warts in other areas.
We aimed in this work to assess the safety and effectiveness of intralesional injection of vitamin D3 injection versus 2% zinc sulfate for the treatment of multiple warts.
We performed our study on 40 patients with multiple warts. The patients were divided into 2 groups, the first group included 20 patients injected with vitamin D3. The second group included 20 patients injected with 2% zinc sulfate.
As regards the response of the target wart, each of the vitamin D3- and 2% zinc sulfate - treated groups showed relatively high cure rate results, 70% and 40% of the treated patients showed complete response respectively. As regards the response of the distant wart each of the vitamin D3-and 2% zinc sulfate-treated groups showed the same result (3 patients for each).
No serious side effects were reported in patients included in this study with vitamin D3. Only reported were local reactions in the form of pain, swelling and erythema. While in 2% zinc sulfate group, most of the patients reported severe intractable pain, one patient developed regional lymphadenopathy and one patient has an atrophic scar at the site of injection.
There was a negative correlation between smoking and older age and the results in vitamin D3 treated group.