الفهرس 
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Abstract
Objective: To compare the effect of Oral Propranolol and Oxytocin, versus Oxytocin only on induction of labor in nulliparas having term pregnancy.
Materials and Methods: A double blind randomized controlled trial performed in labor ward of Ain Shams maternity Hospital in Cairo, Egypt from August 2016 to August 2018 on 211 nulliparas with uncomplicated term pregnancies who had Gestational age of 38–41 weeks, Bishop Score 5 or more. Participants were divided in two groups. In the group A (Propranolol plus Oxytocin group = 106) before the use of Oxytocin, 20 mg Propranolol was administrated orally and then the Oxytocin was initiated. In group B (placebo plus Oxytocin group =105) Oxytocin was used for the induction of labor.
Results: Induction-Contraction interval, duration of latent phase and induction-active phase interval were measured in minutes. All were significantly lower than in group A (Propranolol plus Oxytocin group) (p value=0.001). Duration of active phase measured in minutes was significantly lower than in group A (Propranolol plus Oxytocin group) (p value=0.008). Duration of 2nd stage measured in minutes was significantly lower in group A (Propranolol plus Oxytocin group) (p value=0.002). Propranolol intake reduced need for operative intervention. On average, 20.8 patients would have to receive Propranolol (instead of placebo) for one additional patient to NOT have (Forceps/CS). On average, 12.05 patients would have to receive Propranolol (instead of placebo) for one additional patient to have a maternal side effect. Propranolol had no statistically significant adverse effects on neonates according to APGAR scores at “1 minute” and “5 minutes”. None of neonates delivered in this study needed NICU admission.
Conclusion: According to the data in the current study the use of Propranolol with Oxytocin in induction of labor at term pregnancy may be beneficial in reducing duration of both first and second stages of labor compared to Oxytocin alone without causing any ominous maternal or fetal harm.