الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
consists of a diversity of subjective sensations reflecting responses to events or stimuli. Anxiety is manifested as a number of physical and mental symptoms without logic cause. Mental symptoms of anxiety include discomfort and apprehension. Anxiety may appear in healthy individuals when show unspecific frightening cues. There are symptomatic responses to anxiogenic stimuli including tachycardia, dizziness, muscle tension, nausea and chest or abdominal pain.
Pregabalin was reported in randomized, placebo-controlled clinical trials for treating GAD and has also shown efficacy in clinical trials for neuropathic pain and diabetic neuropathy, respectively. The pharmacologic mechanism of Pregabalin was previously examined in rodents. Studies using series of compounds with structures related to pregabalin propose that high-affinity binding to α2δ are perfectly predicting anxiolytic action in the Vogel conflict model, which is one of the most predictive assays for screening pharmacological agents with anxiolytic-like properties.
The current study provided some evidence that other receptors-mediated response account for the anxiolytic-like effect of pregabalin. Further studies are needed to support the present findings in other models of anxiety in rodents beside important confirmatory ligand binding assays