الفهرس 
Acute Lymphoblastic LeukemiaOnly 14 pages are availabe for public view
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Abstract
ALL is a malignant disorder of lymphoid progenitor cells that proliferate and replace the normal hemaatopioetic cells of the bone marrow. These lymphoblasts replacing the normal bone marrow elements result in a marked decrease in the production of normal blood cells. AML is a clonal malignant disease of haematopoietic tissue resulting from somatic mutation in a pluripotent stem cell or a slightly more differentiated progenitor cell. It is characterized by proliferation of abnormal leukemic cells, principally in the bone marrow, and impaired production of normal blood cells. CD146 (or MUC-18, MCAM) is a membrane glycoprotein neoexpressed in numerous tumors. It was first discovered on metastatic melanoma, where its expression is correlated with tumor progression and dissemination and with a bad prognosis. The present study aimed to study the biological role of CD146 expression on blast cells of ALL and AML patients using flowcytometry that may clarify its biological role in such haematological malignancy