الفهرس 
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Abstract
6. SUMMARY AND CONCLUSION
The marine environment has become an important source for the discovery of natural products that may be structurally unique and contribute significantly for the discovery of novel antimicrobial and other biological bioactive drugs. There are many evidences suggested that the microorganisms which live symbiotically with the marine invertebrates are the true source of many bioactive compounds discovered from marine invertebrates (Martens et al., 2007; Thomas et al., 2010).
In this study, screening the bacterial strains isolated from the marine invertebrates collected from Red Sea for anti microbial activity using standard well diffusion method revealed the presence of five isolates having antifungal activity against Candida albicans (ATTC 10231).
On the other hand, the screening for the biosynthetic gene clusters (PKS-1, II and NRPS) by PCR showed that 60% of the isolates showed at least one type of these genes including the three isolates 25, 74, 75 which showed antifungal activity in the antimicrobial screening test of the current study.
The presence of these biosynthetic genes indicates the biosynthetic potential of these isolates and their ability to produce bioactive metabolites with either antimicrobial activity or any other biological activities and this is considered as an indication for the high value of these isolates if further studies are run on them such as screening for another biological activity, activation of silent genes or genome mining, that successively may result in discovering novel metabolites of therapeutic significance.
As well, the Red Sea marine invertebrates showed high biodiversity illustrated by the 16S rRNA molecular identification of the isolated strains associated with the invertebrates as the isolated strains were found to belong to different bacterial groups represented in Actinobacteria, Alphaproteobacteria, Gammaproteobacteria as well as firmicutes.