الفهرس 
EpidemiologyOnly 14 pages are availabe for public view
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Abstract
SUMMARY
Myomectomy is the method of choice for removing myomas in women who want to preserve their fertility, however massive bleeding is one of its complications.Myomectomy is also performed frequently in patients with infertility with the presence of fibroids.
Misoprostol is a synthetic analogue of natural prostaglandin E1 was approved by the US Food and Drug Administration. The Increase of myometrial contractions caused by misoprostol led to great range of applications in Obstetrics and gynecology.
The aim of this studywas to compare the amount of intraoperative blood loss in cases performing abdominal myomectomy operations preceded by rectal administration of misoprostol 400μg one hour before operation versus cases without receiving this drug.
This study was performed post menstrually up on 50 women thatwere diagnosed havingsingle uterine leiomyoma and were admitted in Gynecology department of Tanta University Hospital to perform myomectomy operation. The age of the patients rangedfrom 30 to 45 years, all were fit for surgery, where the main complaints are abnormal uterine bleeding, dysmenorrhea and pelvic pain.
The patients enrolled in the study were randomly assigned into two equalgroups (25 cases in each group). group I were administered preoperative rectally a single dose of 400 micrograms misoprostol one hour before operation (two tablets of cytotec Pfizer®)(study group).group II 25 patients were performed abdominal myomectomy without administration of misoprostol(control.