الفهرس 
Short statureOnly 14 pages are availabe for public view
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Abstract
The definition and diagnosis of GHD require the discussion of its clinical context at the various phases of life (childhood, transition from adolescence to adult life and adulthood), the biochemical tools and methods used to verify impairment in GH secretion.Most experts accept that ISS is defined as a condition of short stature in which height is below –2 SD scores (SDS) (which is defined as <3rd percentile) for age, sex and the corresponding population, without evidence of a systemic disease, nutritional,psychological, chromosomal disorder or overt hormonal abnormalities. Specifically, children with ISS have a normal size at birth and no deficiency in growth hormone (GH). ISS is a diagnosis of exclusion, so that a thorough medical history, physical examination and additional investigations should be performed,sometimes followed by genetic tests. Mechanism of ISS is not clear.The role of endogenous ghrelin in the growth process of children is unclear. Ghrelin may be involved in the pathogenesis of some forms of short stature.This study was conducted to assess serum ghrelin levels in children with short stature who were growth hormone deficient and those with idiopathic short stature and to find the correlation between serum ghrelin and IGF-1 levels in above mentioned children.