الفهرس 
Phosphides
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Abstract
Summary and Conclusion
Metal phosphides including aluminium and zinc phosphide have
been used as pesticides for many years to protect grains in stores and during
its transportation. The wide spread use of phosphides especially in
developing countries is attributed to being highly effective, cheap and easily
available.
Phosphine gas is the active agent of metal phosphides and responsible
for their toxic effect. Phosphine gas liberated following contact of metal
phosphides with water, moisture in air, or hydrochloric acid in the stomach.
Acute poisoning with metal phosphides may occur either through direct
ingestion of the salts themselves or indirect inhalation of the phosphine gas.
The most common presentation of acute phosphide poisoning is acute
cardiovascular collapse with severe hypotension often refractory to
vasopressors. The management of phosphide poisoning is mostly supportive
with no recorded specific antidote which could explain the associated high
mortality rate.
Corticsteroid therapy plays an important role in stressful conditions as
shock and hypotension due to its role in maintaining the integrity of
endothelial blood vessels and vascular tone by increasing the sensitivity of
vascular smooth muscle to both exogenous and endogenous vasopressors in
addition to its role in treating the critical illness related corticosteroid
insufficiency (CIRCI).