الفهرس 
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Abstract
This study is a prospective study included all neonates with respiratory distress admitted to Neonatal Intensive Care Unit (NICU)-Minia University Hospital from 1st of January to 31st of December 2017. Two hundred eighty cases were admitted, 149 patients (53.2%) were treated with oxygen, 52 patients (18.6%) treated with BCPAP, 79 patients (28.2%) intubated and mechanically ventilated (MV).
The study analyzed the rate of failure and response of management of those patients on bubble CPAP and also compared them with other different treatment modalities according to variable recorded demographic, clinical and laboratory data.
The studied population was subjected to full perinatal and natal history taking, careful examination, and conductance of included cases on bubble CPAP device using nasal prongs as patient interface. Adjustment of CPAP settings, close monitoring of clinical signs and good nursing care were important steps in the study.
Among the 280 cases, 149 patients (53.2%) were treated with oxygen, 52 patients (18.6%) needed to be treated with bubble CPAP, 79 patients (28.2%) needed to be intubated and mechanically ventilated (MV).
Our study showed more incidences of bubble CPAP therapy of RD cases with higher gestational ages and birth weight, milder grades of respiratory distress, absence of sepsis in comparison with mechanical ventilation and vice versa for comparison with nasal oxygen therapy.
During the year of 2017, case fatality rate for RD admitted neonates in Minia NICU University was 45.7%. Highest mortality rate was for mechanically ventilated neonates (92.4%) and lowest mortality rate was for oxygen treated neonates (22.8%) while mortality rate of bubble CPAP treated neonates was 40.4%.
Analysis of bubble CPAP cases showed positive correlation of bubble CPAP success with higher gestational ages, birth weight, and sepsis absence.
The results showed success rate 92.3% for NBW, 77.8% for LBW while failure rate 81.8% for VLBW and 80% for ELBW. They also showed success rate 83.3% for GA≥37 weeks and 60% for GA between 30-36 weeks while failure rate 100% for GA≤29 weeks.
Laboratory results showed higher CRP levels at failure of bubble CPAP treatment (40±34) in comparison to (5±6) at success.
Among the 280 cases of RD, 18.6% were managed with bubble CPAP. Rate of success was 57.7%, failure ratio was 42.3%. Among the failed cases, 30.8% were ventilated, and 11.5% were deteriorated and died.