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العنوان
Synthesis of Some New Modified C-Furyl /Glycosides
المؤلف
.El Hema, Hagar Sabry Nabawy
هيئة الاعداد
باحث / هاجر صبري ىبوي الحما
مشرف / عادل عبد الهادي ىصار
مشرف / محمد عبد الله حواطه
مناقش / محمد عماد عذب
الموضوع
Carbohydrate analogues occurring C-nucleosides .C-glycosylation
تاريخ النشر
2019
عدد الصفحات
153 P.:
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الكيمياء
الناشر
تاريخ الإجازة
16/2/2022
مكان الإجازة
جامعة المنوفية - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

C-Glycosyl derivatives represent basic structural constituents in a variety of compounds, which are recognized for their antibiotic, antitumoral, and antiplatelet aggregation activities in addition to potential enzyme inhibitory effect.
In this investigation, when 3-Carbohydrazide-5-C-(l,4-anhydro-β-D-erythro-tetrofuranosyl)-2-methylfuran (90) was treated with phenylisothiocyanate in absolute ethanol under reflux to afford 1-acetyl-4-phenyl thiosemicarbazide derivative 91 in 80% yield.
When the hydrolysis of 91 was carried out under acidic conditions by sulfuric acid, leads to cyclization with sulfur atom to give the 1,2,4-thiadiazole derivative 92 in 60% yield.
When the cyclization of 91 was carried out under alkaline conditions, the nucleophilicity of N-4 is enhanced and leads to cyclization with the carbonyl carbon atom to give the 1,2,4-triazole derivative 93 in 75% yield (Scheme 21).