الفهرس 
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Abstract
1. This study was carried out from March to June 2015. A total of 200 children receiving regular blood transfusion were taken randomly. They were registered for transfusion management. Out of 200 patients there were 137 Males, and 33 females with a mean age 9.90 yrs attending to hematology Clinic of EL-Minia University Hospital, Hematology clinic of EL-Minia insurance Hospital, and Regional Blood Transfusion Center in EL-Minia; they were randomly selected from community.
The aim of this study is to determine the prevalence of Hepatitis C among frequently blood transfused children.
All children were subjected to:
- A full medical history was composed of questions regarding different variables (age, sex, residence, frequency of blood transfusion & presence of any liver disease), thoroughly clinical examination for all patients with stress on signs of liver affection such as jaundice, hepatospleenomegaly.
- The study was explained to all participants using the consent form.
- Blood sample was collected in morning for biochemical assays hepatitis C virus (HCV), (CBC), (ALT), (AST), (TSB),serum ferritin.
Results:
- We found according to the Frequency of HCV for all studied children where 77 (38.5 %) were confirmed positive for anti- HCV- antibodies. The remaining 123 (61.5 %) were seronegative.
- A high significant difference was found according to the age group. Patients above ≥ 7 years; 72 (93.5%) patients were positive, while patients from (0-6) years were 5 (6.4%).
- A high significant difference was found according to the sex; 64 (83.12%) were males and 13 (16.88%) were females with (P- 0.001).
- A high significant difference was found according to the diagnosis; 77 (100%) patients with HCV seropositive was β-Thalassemia.
- There was a significant difference (P=0.02) in Hb levels between patients with HCV seropositive and patients with HCV seronegative.
- A high significant difference (P = 0.001) in Serum Ferrtin between the HCV seropositive patients and the HCV seronegative ones.
- No significant difference in P-value according to the Total serum bilirubin (TSB), ALT, AST.
- A high significant were between the Male percent which was 83.5%, and the female percent 16.5%.
- A high significant difference was found according to the Frequency of diagnosis for the HCV seropositive patients in all study group which was β-Thalassemia (86%), G6PD (13%), and VonWillbrand (1%).