الفهرس 
Breast CancerOnly 14 pages are availabe for public view
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Abstract
The present work was carried out to study the utility of some serum biomarkers in the diagnosis of breast cancer.
This study was carried out on ninety subjects classified into three groups:
1. group I: this group composed of twenty apparently healthy volunteers was included as normal controls aged from 35-51 years with a mean of 42.1 ± 2 years. None of the healthy controls take any medication or dietary supplements.
2. group II: this group composed of twenty patients diagnosed with benign fibroadenoma lesions aged from 35-52 years with a mean of 43.3 ± 1.2 years. They were attending the National Cancer Institute, Cairo University Hospitals, Egypt.
3. group III: This group composed of fifty cases of confirmed early diagnosed primary breast cancer patients most of them with invasive ductal carcinoma type, aged from 38-55 with a mean of 46.1 ± 5.2 years of different stages prior to surgery attending the National Cancer Institute, Cairo University Hospitals, Egypt. They were diagnosed according to typical clinical pattern. Full history was taken for all patients including family history of breast cancer, presence of any types of malignancy and previous treatment with chemotherapy. All patients were newly diagnosed cases, did not receive chemotherapy, radiotherapy or subjected to surgical resection of the cancer.
Four parameters were measured in the serum of both patients and healthy controls groups. These parameters were:
- Serum integrin αvβ3.
- Serum vitronectin.
- Serum CA15.3
- Serum CEA.