الفهرس 
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Abstract
Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result in devastating consequences. The principle mechanisms underlying neurological damage in HIE resulting from hypoxemia and/or ischemia is deprivation of glucose and oxygen supply which cause energy failure.
DKK1 is a secreted protein involved in embryonic development and known as a potent inhibitor of the Wnt signaling pathway, which plays a critical role in cell patterning, proliferation, and fate determination during embryogenesis.
• Aim of the work:
Was to measure the serum Dickkopf-1 level in neonates with HIE and to study its relation to the neurodevelopmental outcome in those neonates in comparison to healthy neonates.
• Results:
In our study we reported that there was no effect of gestational age, neonatal age, birth weight, sex and mode of delivery on serum DKK1 level in studied groups.
Also, our study revealed that according to laboratory data finding there was a high levels of blood urea, serum creatinine, SGOT, SGPT, K and low levels of PH,base excess, Hb, Ca, Na, platelets and WBCs count in neonates with HIE.
Moreover there were significant differences as regarding Hb level, platelets count, PH, base excess, urea, creatinine, SGOT, SGPT, Na, K and Ca levels but non significant difference as regarding WBCs count between full term HIE neonates and full term controls.
There were significant differences as regarding Hb level, platelets count,WBCs count, PH, base excess, blood urea, serum creatinine, SGOT, SGPT, Na, K and Ca levels between preterm HIE neonates and preterm controls.
A significant negative correlation between serum DKK1 level and Hb level, platelets count, PH, base excess and Na level among HIE neonates.
Also, a significant positive correlation with blood urea serum ceratinine, SGOT, SGPT and K level among HIE neonates.
Also, a non-significant negative correlation with WBCs count, Ca level among HIE neonates.
Moreover in our study we found that Apgar score which was done at1 minute and 5 minutes after delivery was less in in all HIE neonates in comparison to controls and in each HIE neonates group (fullterm & preterm) in comparison to the corresponding control group and there was high statistical significant difference between these groups and significant negative correlation between serum DKK1 level and Apgar score in HIE neonates.
Furthermore, we found that serum DKK1 level is significantly higher in neonates with HIE than controls, also serum DKK1 level had significant positive correlation with the degree of hypoxia in HIE neonates.