الفهرس 
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Abstract
Summary Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that preferentially affects women from early adulthood through mid-adulthood ( Somers et al., 2014).
SLE is characterised by autoantibody formation against nuclear antigens with resultant inflammation in organs such as the kidney, skin and joints. SLE is notorious for its markedly heterogeneous clinical phenotype, with a multifactorial aetiology that depends on genetic, epigenetic and environmental influences (Tsokos ., 2011).
In SLE, hs-CRP concentration rises sharply during acute inflammatory conditions. Positive correlations have been reported between hs-CRP levels and SLE disease activity index (SLEDAI) (Umare et al ., 2017)
The aim of this study was To assess serum level of high sensitivity C-reactive protein (hs-CRP level) in systemic lupus erythematosus (SLE) patients and find its Correlation with disease activity and damage.
This study was conducted on 50 clinically diagnosed SLE patients And 22 healthy controls.
The patients were diagnosed according to Systemic Lupus International Collaborating Clinics ( SLICC) classification criteria for SLE (petri et al.,2012).
All were subjected to full clinical history and examination, complete blood count, ESR, C-reactive protein, ANA , Ds DNA , C3, C4,liver enzymes serum creatinine ,uric acid , Complete urine analysis ,24 hours urinary protein, serum hs-CRP by ELISA technique.
Renal Biopsy was done and classified according to the to the classification of lupus nephritis by the International Society of Nephrology/Renal Pathology Society (ISN/RPS) (Weening et al.,2004).
This study demonstrated the following:
serum hs-CRP levels are higher in SLE patients than healthy subjects.
serum levels hs-CRP were significantly correlated with the SLEDAI scores ,CRP, ESR and URIC ACID , serositis, neurologic disease& lupus nephritis .
Conclusion
The study concluded that, hs-CRP concentrations were significantly elevated in SLE patients and correlated with the SLEDAI score. Indicating their direct involvement in inflammatory conditions associated with disease.