الفهرس 
Overview of antipsychotic medicationsOnly 14 pages are availabe for public view
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Abstract
Summary
Antipsychotic drugs are used mainly for treatment of schizophrenia and
other psychiatric disorders as delusional disorder and bipolar disorder. These
drugs are classified as first-generation (typical or conventional) antipsychotics
and second-generation antipsychotics (atypical antipsychotics).
Because of side effects associated with first generation especially
extrapyramidal side effects, second generation antipsychotics were introduced
in 1990. The Second generation has a lower risk to cause EPS as acute
dystonia, akathisia, and tardive dyskinesia compared with first generation but
associated with more risk of cardiac and metabolic abnormalities; weight gain,
hyperlipidemia and glucose intolerance. These properties are due to their
difference in receptor profiles but D2 receptor antagonism in the brain is still
considered the primary common pharmacodynamic target for psychotropic
drugs.
Additionally, most cases of accidental or intentional antipsychotic
poisoning will remain asymptomatic or develop only mild to moderate toxicity.
Therefore, death after antipsychotic intoxication is a rare complication
especially if treatment is initiated in proper time. Clinical manifestations of
antipsychotic toxicity are CNS depression, miosis or mydriasis, orthostatic
hypotension, cardiac conduction disturbances, atrial and ventricular
dysrhythmias, anticholinergic manifestations and uncommonly seizures.
Hence, the aim of this work was to assess the pattern and prognosis of
cases with acute antipsychotic poisoning admitted to Tanta University Poison
Control Unit.
Summary
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The present study was conducted on cases with antipsychotic overdose
admitted to Tanta University Poison Control unit throughout the period