الفهرس 
INTRODUCTION & AIM OF WORKOnly 14 pages are availabe for public view
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Abstract
Preeclampsia is a multi-system disorder characterized by new onset of hypertension and either proteinuria or end-organ dysfunction in the last half of pregnancy. Although most affected pregnancies deliver at term or near term with good maternal and fetal outcomes, these pregnancies are at increased risk for maternal and/or fetal mortality or serious morbidity, VEGF is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis ,as it creates new blood vessels during embryonic development, new blood vessels after muscle injury, following exercise, and new vessels or collateral circulation to bypass blocked vessels The aim of this study was to prove association between vascular endothelial growth factor VEGF C/A 2578 gene polymorphism and developing preeclampsia among Egyptian population.
This association was done to shed light on pathophysiology of preeclampsia and to identify risk assessment.
The study was conducted on 50 subjects:
20 unrelated normotensive pregnant women more than 20 weeks gestation and their age matched with patient group and 30 pregnant women diagnosed as preeclamptic.
All individuals included in this study were subjected to:
Full history taking.
Routine clinical & laboratory examination including measuring;
blood pressure.
protein concentration in urine.
Specific laboratory investigation
Detection of vascular endothelial growth factor VEGF C/A 2578 gene polymorphism by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
This work revealed the following results:
CA genotype frequency of VEGF gene (C2578A) was higher in patient group than the control group 13/30 (43.33%) versus 4/20 (20%) while control group had higher CC genotype frequency than patient group 16/20 (80%) versus 17/30 (56.66%) .Yet this difference did not reach a statistical significance (P = 0.079).
A allele frequency was higher in patient group than the control group 13/60 (21.66%) versus 4/40 (10%). while C allele frequency was higher in control group than the patient group36/40 (90%) versus 47/60 (78.33%). Yet this difference did not reach a statistical significance (P = 0.061).
Risk to PE is 2.1 times in women having CA genotype and A allele than those with CC genotype and C allele according to odd ratio (OR = 2.1 & 95% CI = 0.8-5.7).